RBC ( Definition, Variation in RBC shape, Size and Function of RBCs)

RBCs(Erythrocytes):- RBC is a circular biconcave non-nucleated disc. RBC depends entirely on glucose metabolism for its energy supply.

Structure of RBCs:- RBC contains hemoglobin which takes pink color with Lishman's stain. Cell membrane that contains circular pores which are concerned with water and electrolytes.

Composition 

1). 62.5% - H2O

2). 35% - Hemoglobin

3). 2.5% - 

a). Sugar    - Glucose

b). Lipids   - Cephalin, Cholestrol

c). Protein  - Glutathione, albumin like in soluble protein those act as a reducing agent which protects HB.

d). Enzymes of glycolytic synthesis - carbonic anhydrase catalase.

e). Vitamin derivative

f). Ions - Na+, K+, Ca2+, PO4 -3, SO4 -2

g). Diameter - 6.5-8.8 μm

RBCs Count:- 

1). At Birth:- 6-7 Million/μl.

2). Adults Male: 5-6 Million/μl.

                  average (5.5 Million/μl)

3). Adults Female:- 4.5-5.5 Million/μl

                  average (4.8 Million/μl)

Life span:- 120 days

Functions of RBCs:-

1). It takes O2 from lung to tissue and co2 tissue to lungs

2). Helps in identifying blood groups as it contains blood-specific substances.

Ex:- Antigen on its surface.

[Variations in shape and size and structure of RBC]

1). Anisocytosis:- Variation in the size of RBC called an Anisocytosis.

2). Poikilocytosis:- Variation in the shape of RBC.

3). Spherocytosis:- Spherical shape RBCs.

4). Anemia:- Reduction in number of RBCs less than anemia 4 Million/μl or HB less than 12 hp<gm/dl.

5). Polycythemia RBC count more than 7 million/microliter