Granulocytes WBCs
1). Neutrophil (3000-6000/μL)
2). Eosinophils (150-300/μL)
3). Basophil (10-100/μL)
Neutrophil or Polymorphonuclear Leucocyte:-
Size:- 10-14 μm diameter
Nucleus:- Purple in color
Cytoplasm:- Slight Bluish in color and granular.
Life span:- 6-30 Hours.
Diagram:-
Function:-
a). Phagocytosis:- The first line of defense against bacterial infection.
b). Response to bacteria pyrogen.
Neutrophilia:- Means increase in Neutrophil count
Causes:- I). Physiological
II). Pathological
I). Physiological:- (a). After Excercise
(b). After Injection of Epinephrine
(c). Pregnancy
II). Pathological:- (a). Acute pyogenic infection.
(b). Tissue Destruction Eg:- Burns after Hemorrhage
(c). Myocardial Infarction.
(d). After surgery
Neutropenia:- Decrease in the Neutrophil count.
Causes:-
I). In Children
II). Typhoid
III). Viral Infection
IV). Bone marrow depression or suppression.
Eosinophil:-
Size:- 10-14 μm diameter.
Nucleus:- Purple in color cell usually bilobed.
Cytoplasm:- Pink in color (Acidophilic) granular.
Diagram:-
Function:-
I). Mild phagocytosis because of less motile than neutrophil.
II). Produce allergic reaction toward the inflammatory mediator (Histamins Bradykinin).
III). Eosinophil granules release chemicals which is Toxic to Larve of parasites.
Eosinophilia:- Increase in Eosinophil.
Causes:-
I). Allergic condition Eg:- Bronchial asthma.
II). Parasite infection Eg:- Warms
III). Skin Disease.
Eosinopenia:- Decrease in Eosinophil counts after Injection of corticosteroids (because of increase in spleen, lungs and by their destruction in the blood).
Basophil:- Size:- 10-14 μm, Nucleus: as in Eosinophil.
Cytoplasm:- Slightly basophil granular.
Function:-
I). Mild Phagocytosis.
II). Hypersensitivity reaction.
III). Act as a Heparin(Anticoagulant).
Basophilia:- Increase in number of Basophils.
Causes:-
I). Chickenpox
II). Smallpox
III). Tuberculosis
Basopenia:- Means Decrease in basophil count.
Causes:-
I). After the Injection of Glucocorticoids.
II). Drug-induced reaction.
Diagram:-
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